The Lipid Raft - Associated Protein CD 98 is Required 1 for Vaccinia Virus Endocytosis
نویسندگان
چکیده
3 4 Nina Schroeder, Che-Sheng Chung, Chein-Hung Chen, Chung-Lin Liao and Wen Chang 5 6 Institute of Molecular Biology, Academia Sinica, 128 Academia Road, Sec. 2, Nangang, 7 Taipei 11529, Taiwan, Republic of China 8 2 The Genomics Research Center, Academia Sinica, 128 Academia Road, Sec. 2, Nangang, 9 Taipei 11529, Taiwan, Republic of China 10 11 12 Running title: Role of CD98 in vaccinia virus entry 13 14 Corresponding author: Dr. Wen Chang 15 [email protected] 16 17 18 19 20 21 22 23 24 25 Copyright © 2012, American Society for Microbiology. All Rights Reserved. J. Virol. doi:10.1128/JVI.06610-11 JVI Accepts, published online ahead of print on 15 February 2012
منابع مشابه
The lipid raft-associated protein CD98 is required for vaccinia virus endocytosis.
Mature vaccinia virus (vaccinia MV) infects a broad range of animals in vivo and cell cultures in vitro; however, the cellular receptors that determine vaccinia MV tropism and entry pathways are poorly characterized. Here, we performed quantitative proteomic analyses of lipid raft-associated proteins upon vaccinia MV entry into HeLa cells. We found that a type II membrane glycoprotein, CD98, is...
متن کاملVaccinia virus penetration requires cholesterol and results in specific viral envelope proteins associated with lipid rafts.
Vaccinia virus infects a wide variety of mammalian cells from different hosts, but the mechanism of virus entry is not clearly defined. The mature intracellular vaccinia virus contains several envelope proteins mediating virion adsorption to cell surface glycosaminoglycans; however, it is not known how the bound virions initiate virion penetration into cells. For this study, we investigated the...
متن کاملInterfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By Sambucus Nigra
Sambucus nigra (elder) are broadly used species to treat microbial infections. Thepotential antiviral activity and mechanism action of elder fruit (EF) in human epithelium cell(A549) cultures infected with H9N2 influenza virus were determined. The effect of variousconcentrations of EF on influenza virus replication was examined by using virus titration,quantitative real time RT-PCR, fusion and ...
متن کاملA novel cellular protein, VPEF, facilitates vaccinia virus penetration into HeLa cells through fluid phase endocytosis.
Vaccinia virus is a large DNA virus that infects many cell cultures in vitro and animal species in vivo. Although it has been used widely as a vaccine, its cell entry pathway remains unclear. In this study, we showed that vaccinia virus intracellular mature virions bound to the filopodia of HeLa cells and moved toward the cell body and entered the cell through an endocytic route that required a...
متن کاملInterfering With Lipid Raft Association: A Mechanism to Control Influenza Virus Infection By Sambucus Nigra
Sambucus nigra (elder) are broadly used species to treat microbial infections. Thepotential antiviral activity and mechanism action of elder fruit (EF) in human epithelium cell(A549) cultures infected with H9N2 influenza virus were determined. The effect of variousconcentrations of EF on influenza virus replication was examined by using virus titration,quantitative real time RT-PCR, fusion and ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2012